Aging & Disease (A&D) is a peer-reviewed, open access online journal dedicated to publishing novel and high-impact findings that advance understanding of the biology of aging, the pathophysiology of age-related diseases, and innovative therapeutic strategies targeting conditions that affect the elderly population.

Diseases of interest include, but are not limited to: stroke, Alzheimer’s disease, Parkinson’s disease, epilepsy, dementia, depression, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, diabetes, and hypertension. Submissions based on studies using animal models, human tissues, or cell-based systems are welcome.

Manuscripts in the following areas are of particular interest:

A) Biology of Aging

  1) Cellular Senescence and Senolytics (e.g., senescent cell clearance, SASP inhibition)

  2) Epigenetic Aging Biomarkers (e.g., DNA methylation clocks, histone modifications)

  3) Mitochondrial Dysfunction (e.g., oxidative stress, impaired bioenergetics)

  4) Autophagy and Proteostasis (e.g., protein aggregation, impaired clearance mechanisms)

  5) Inflammaging and Immunosenescence (e.g., chronic inflammation, immunosenescence)

  6) Telomere Shortening (e.g., replicative senescence, telomere maintenance)

  7) Gut Microbiome in Aging (e.g., dysbiosis, gut-brain axis dysfunction)

  8) NAD+ Metabolism (e.g., NAD+ decline, metabolic dysregulation)

  9) Dietary Restriction and Fasting (e.g., nutrient-sensing pathways, intermittent fasting)

  10) Stem Cell Aging (e.g., reduced regenerative capacity, niche deterioration)

B) Pathophysiology of Age-Related Diseases

  1) Neurodegeneration (e.g., Alzheimer's, Parkinson's, tauopathies)

  2) Vascular Aging and Stroke (e.g., endothelial dysfunction, blood-brain barrier integrity)

  3) Metabolic Syndrome (e.g., diabetes, obesity-related inflammation)

  4) Osteoporosis (e.g., hormonal regulation, osteoblast/osteoclast imbalance)

  5) Cardiac Aging (e.g., myocardial fibrosis, cellular senescence)

  6) Cancer and Aging (e.g., immune evasion, DNA repair deficits)

  7) Macular Degeneration (e.g., oxidative stress, retinal inflammation)

  8) Immunosenescence (e.g., immunosenescence, impaired vaccine responses)

  9) Arthritis (e.g., cartilage breakdown, inflammatory signaling)

  10) Sarcopenia (e.g., anabolic resistance, mitochondrial dysfunction)

C) Novel Treatments for Diseases Afflicting the Elderly

1)      1) Senolytic Therapies (e.g., drugs targeting senescent cells, SASP inhibitors)

2)      2) Immunotherapies for Neurodegeneration (e.g., antibody therapies, immunomodulation for Alzheimer's and Parkinson's)

3)      3) Gene and Cell Therapies (e.g., CRISPR-based gene editing, stem cell transplantation)

4)      4) Microbiome-Based Interventions (e.g., probiotics, fecal microbiota transplants for age-related diseases)

5)      5) NAD+ Boosting Strategies (e.g., NMN, NR supplementation for metabolic and neurodegenerative disorders)

6)      6) Anti-inflammatory and Immune-Modulatory Treatments (e.g., targeting inflammaging pathways, cytokine blockers)

7)      7)  Regenerative Medicine and Tissue Engineering (e.g., engineered tissues for osteoarthritis, bioartificial organs)

8)      8) Precision and Personalized Medicine Approaches (e.g., genetic profiling, tailored therapeutics for cancer and cardiovascular diseases)

9)      9) Novel Metabolic Modulators (e.g., mTOR inhibitors, AMPK activators)

10)    10) Advanced Drug Delivery Systems (e.g., nanoparticle-based therapies, blood-brain barrier crossing methods)