Special Issue: Strengthening collaborations in ageing research: impaired resilience from 'bench to bedside'

Deadline for submission of article: October 1, 2024

Ageing is a complex heterogeneous process, both in terms of fundamental mechanisms and clinical manifestations. The 12 'hallmarks of ageing' are recognised as counterparts to the ageing process by discovery and biomedical scientists. However, laboratory studies have commonly been performed in healthy older adults without clinical assessment. Conversely, clinicians involved in the healthcare of older adults may have expertise in the identification of frailty, long-term conditions, and overall holistic management, but commonly do not have expertise in fundamental mechanisms of ageing. Indeed, many clinicians involved in healthcare of older people struggle to understand the relevance of ageing processes to their clinical practice. This leads to a disconnect in terms of how research is conducted, interpreted, and disseminated, which in itself leads to a further cycle of siloed working. In this special issue, we are aiming to publish research that involves collaboration between clinicians, fundamental scientists, physiologists, and/or bioinformaticians. Articles describing any experimental methodology will be considered, but these should relate directly to clinical manifestations of impaired resilience with ageing in the interpretation of results (e.g., frailty, sarcopenia, cognitive spectrum disorders including delirium, falls, outcomes from infection or acute illness). This issue will consider articles including original articles, reviews, and short communications.

Guest Editor

Dr. Carly Welch, MBChB, PhD

Senior Lecturer and Consultant Geriatrician

Department of Twin Research, Kings College London, UK

Email: carly.welch@kcl.ac.uk

Special Issue: Unveiling the relation between cellular aging, epigenetics, and cancer

Deadline for submission of article: 20 December, 2025

Cellular aging describes the process of deterioration and functional decline in cells as they age. Cellular aging refers to the overall process of aging at the cellular level, encompassing various molecular and physiological changes that occur in cells over time. Aging, a universal and inevitable process, has long been a subject of fascination and scientific inquiry. Emerging evidence suggests that the intricate relationship between aging, epigenetics, and cancer holds the key to unraveling the complexities of this natural phenomenon. Epigenetic modifications, such as DNA methylation and histone modifications, have been recognized as crucial mediators in the aging process, influencing gene expression patterns and cellular function. As individuals age, the epigenome undergoes progressive changes, leading to a multitude of age-associated disorders, including cancer. Importantly, the epigenetic clock, a biological measure of age based on DNA methylation patterns, has emerged as a powerful tool in predicting disease prognosis and tracking the aging process. By understanding the dynamic nature of DNA methylation during aging, researchers have uncovered its potential as a 'prophet' of age-related outcomes, including the risk of developing cancer. Notably, the development of epigenetic drugs that target specific pathways involved in age-related diseases, such as cancer, has sparked hope for novel anti-aging strategies.

This special issue invites the submission of Reviews, Mini-Reviews, Perspectives, and Original Articles that provide novel insights into the relationship between aging, epigenetics, and cancer.

 

Guest Editor:

Prof.UMK, Dr. habil.Dr.med.vet. Pawel Kordowitzki, Dipl. ECAR

University Professor

Department of Basic and Preclinical Sciences

Nicolaus Copernicus University, Torun, Poland

Email: p.kordowitzki@umk.pl

Special Issue: Natural Biomaterials and Advanced Medical Devices in Age-Related Diseases

Deadline for submission of article: April 1, 2025

Natural biomaterials and advanced medical devices play a crucial role in addressing age-related diseases within the field of biomedicine. The development and application of these materials offer expanded options and possibilities for the treatment of conditions associated with aging, including osteoporosis, arthritis, Alzheimer's disease, and others. Natural biomaterials, such as polyesters, proteins, and polysaccharides, are utilized to repair damaged tissues, promote cell regeneration, and develop biosensors for monitoring patients' physiological states, thereby potentially slowing the aging process. Advanced medical devices, such as nano-drug carriers, 3D printing scaffolds and microneedle, facilitate precise drug delivery and minimize side effects. The synergy between the biocompatibility of natural materials and the high efficiency and functionality of advanced materials significantly enhances the prevention and treatment of age-related diseases, consequently improving patients' quality of life. Therefore, understanding the pivotal role of natural biomaterials and novel medical devices in geriatric diseases is essential for developing effective treatments.

This special issue invites the submission of Review, Mini-Review and Opinion that provide novel insights into the use of natural biomaterials and innovative medical devices for the treatment of age-related diseases.

Guest Editor,

Dai-Xu Wei, Ph.D.,

Professor,

School of Medicine, Faculty of Life Sciences and Medicine, Northwest University, Xi’an, 710069, China

Email: daviddxwei@163.com

 

Guest Editor,

Quanbo Ji, Ph.D., M.D.,

Associate Professor,

Department of Orthopaedics, Chinese PLA General Hospital

Beijing, 100853, China

Email: quanbo301@163.com

Special Issue:  Mitochondrial Dysfunction in Aging and Age-related Disorders

Deadline for submission of articles: April 1, 2025

Special Issue Information:

    Alterations in mitochondrial bioenergetics, biogenesis, mitophagy and oxidative stress originating from mitochondria are closely linked to aging and the development of age-related diseases. Age-related diseases are very complex process, and the various factors involved in its aetiology are not yet completely understood. The main theme of this Special Issue centers on exploring mitochondrial dysfunction in aging and the development of age-related diseases and the signaling pathways associated with mitochondrial bioenergetics, biogenesis, mitophagy, and reactive oxygen species generation. Additionally, we aim to stimulate constructive discussions about mitochondria-targeted therapies under development and shed light on the latest advancements in understanding aging and disease mechanisms, biomarkers, and therapies related to neurodegeneration. We are inviting submissions of review, mini-review, commentary, or perspective articles, and novel communications that delve into the molecular mechanisms underlying the significance of mitochondria in neurodegenerative disease processes.

 

Guest Editor

Aida Adlimoghaddam PhD, CRQM

Assistant Professor

Neurology Department, SIU School of Medicine

Springfield, IL, USA

Email: aadlimoghaddam72@siumed.edu     

Special Issue: 'Recent advances in aging-related diseases: Evidence from molecular mechanisms to interventions and therapies

 

Deadline for submission of articles: July 30, 2024

 

Special Issue Information:

Aging is an irreversible pathophysiological process that occurs with a decline in tissue and cell function and a significant increase in the risk of various aging-related diseases, including neurological, cardiovascular, metabolic, and immune system diseases. As aging is one of the major risk factors for most chronic diseases, understanding the aging process is expected to facilitate the identification of therapeutic targets for age-related diseases and the development of suitable pharmacological agents for approved clinical use in the future. Research on aging mechanisms and intervention methods is important in improving human health and increasing lifespan. Currently, great progress has been made in research on the molecular mechanisms of aging, and progress has been made in understanding the biological and genetic mechanisms of the aging process, as well as a deeper understanding of the pathogenesis of aging. However, these findings are still far from being able to delay human aging and reduce the occurrence of aging-related diseases. Considering the aging of the population, anti-aging and healthy aging are undoubtedly important tasks of public health organizations, scientific research units, and drug research development centers. Although there are many challenges to research on aging and aging-related diseases, many questions still need to be addressed. This special issue aims to publish reviews, opinions, commentaries, letters to the editor, and correspondence describing the mechanisms related to pharmacological, non-pharmacological interventions and therapeutic strategies for aging-related diseases. 

 

Guest Editors:

 

Nasrollah Moradikor, Ph.D.

Research Director and Head of Brain Aging and Dementia Group

Center for Neuroscience Research, 0105 Tbilisi

Georgia 

Email: moradikor.nasroallah@yahoo.com

 

Mahdi Esmaeilzadeh, Ph.D.

Head of Cell and Molecular Biology Department

Center for Neuroscience Research, 0105 Tbilisi

Georgia

Email: mehdi_dna@yahoo.com