Aging and disease

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01 October 2018. VOL 9, ISSUE 5 Previous Issue Next Issue

Orginal Article

The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson’s Disease
Yong-Fei Zhao, Qiong-Zhang, Jian-Feng Zhang, Zhi-Yin Lou, Hen-Bing Zu, Zi-Gao Wang, Wei-Cheng Zeng, Kai-Yao, Bao-Guo Xiao

2018, 9 (5): 785-797 | DOI: 10.14336/AD.2017.1028

PDF (1128KB)
The Effect of Aquaporin-4 Knockout on Interstitial Fluid Flow and the Structure of the Extracellular Space in the Deep Brain
Ze Teng, Aibo Wang, Peng Wang, Rui Wang, Wei Wang, Hongbin Han

2018, 9 (5): 808-816 | DOI: 10.14336/AD.2017.1115

PDF (1036KB)
Limb Ischemic Conditioning Improved Cognitive Deficits via eNOS-Dependent Augmentation of Angiogenesis after Chronic Cerebral Hypoperfusion in Rats
Changhong Ren, Ning Li, Sijie Li, Rongrong Han, Qingjian Huang, Jiangnan Hu, Kunlin Jin, Xunming Ji

2018, 9 (5): 869-879 | DOI: 10.14336/AD.2017.1106

PDF (889KB)

Short Communication

Low Molecular Weight Adiponectin Increases the Mortality Risk in Very Old Patients
Stefano Rizza, Marina Cardellini, Alessio Farcomeni, Pasquale Morabito, Daniele Romanello, Giovanni Di Cola, Maria Paola Canale, Massimo Federici

2018, 9 (5): 946-951 | DOI: 10.14336/AD.2017.1117

PDF (275KB)

Orginal Article

Searching for Factors Raising the Incidence of Metabolic Syndrome Among 45-60-Year-Old Women
Szkup Małgorzata, Brodowski Jacek, Owczarek Aleksander Jerzy, Choręza Piotr, Jurczak Anna, Grochans Elżbieta

2018, 9 (5): 831-842 | DOI: 10.14336/AD.2017.1027

PDF (600KB)
Gender Differences among Elderly Patients with Primary Percutaneous Coronary Intervention
Binquan You, Bingbing Zhu, Xi Su, Feng Liu, Bingyin Wang

2018, 9 (5): 852-860 | DOI: 10.14336/AD.2017.1129

PDF (541KB)

Review

Nitrate and Nitrite in Health and Disease
Linsha Ma, Liang Hu, Xiaoyu Feng, Songlin Wang

2018, 9 (5): 938-945 | DOI: 10.14336/AD.2017.1207

PDF (546KB)

Orginal Article

Transcultural Adaptation and Validation of the Spanish Bristol Foot Score (BFS-S)
Emmanuel Navarro-Flores, Marta Elena Losa-Iglesias, Ricardo Becerro-de-Bengoa-Vallejo, Daniel Lopez-Lopez, Juan Manuel Vilar-Fernandez, Patricia Palomo-Lopez, Cesar Calvo-Lobo

2018, 9 (5): 861-868 | DOI: 10.14336/AD.2017.1215

PDF (428KB)
Progranulin Deficient Mice Develop Nephrogenic Diabetes Insipidus
Stefanie Hardt, Lucie Valek, Jinyang Zeng-Brouwers, Annett Wilken-Schmitz, Liliana Schaefer, Irmgard Tegeder

2018, 9 (5): 817-830 | DOI: 10.14336/AD.2017.1127

PDF (1597KB)
Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia
Patricia Sosa, Elena Alcalde-Estevez, Patricia Plaza, Nuria Troyano, Cristina Alonso, Laura Martínez-Arias, Andresa Evelem de Melo Aroeira, Diego Rodriguez-Puyol, Gemma Olmos, Susana López-Ongil, María P. Ruíz-Torres

2018, 9 (5): 769-784 | DOI: 10.14336/AD.2017.1214

PDF (1105KB)

Review

Mitochondria in Ischemic Stroke: New Insight and Implications
Fan Liu, Jianfei Lu, Anatol Manaenko, Junjia Tang, Qin Hu

2018, 9 (5): 924-937 | DOI: 10.14336/AD.2017.1126

PDF (705KB)

Orginal Article

Age-related Deficits in Recognition Memory are Protocol-Dependent
Diano F. Marrone, Elham Satvat, Anuj Patel

2018, 9 (5): 798-807 | DOI: 10.14336/AD.2017.1223

PDF (483KB)

Review

Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging
Maxime Fournet, Frédéric Bonté, Alexis Desmoulière

2018, 9 (5): 880-900 | DOI: 10.14336/AD.2017.1121

PDF (764KB)

Cover Illustration

01 October 2018. Vol.9 No.5
Figure 4. Changes of in ISF flow in the ECS between the caudate nucleus and cortex. In normal deep brain, ISF flows from the caudate nucleus to the cortex along myelinated fibers, whereas it is cleared from the brain along paravenous routes in the cortex. The flow of ISF is facilitated by AQP4-dependent astroglial water flux, which drives fluid dispersion into the subarachnoid CSF. In the brains of knockout rats, AQP4 deficiency led to obstruction of ISF clearance and accumulation of ISF in the cortex and caudate nucleus, resulting in a decrease in tortuosity and an increase in the volume fraction and molecular diffusion rate in the ECS within the caudate nucleus.

[Detail]

Cover Illustration

Figure 4. Changes of in ISF flow in the ECS between the caudate nucleus and cortex. In normal deep brain, ISF flows from the caudate nucleus to the cortex along myelinated fibers, whereas it is cleared from the brain along paravenous routes in the cortex. The flow of ISF is facilitated by AQP4-dependent astroglial water flux, which drives fluid dispersion into the subarachnoid CSF. In the brains of knockout rats, AQP4 deficiency led to obstruction of ISF clearance and accumulation of ISF in the cortex and caudate nucleus, resulting in a decrease in tortuosity and an increase in the volume fraction and molecular diffusion rate in the ECS within the caudate nucleus.