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Predictive Value of Pin1 in Cervical Low-Grade Squamous Intraepithelial Lesions and Inhibition of Pin1 Exerts Potent Anticancer Activity against Human Cervical Cancer
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Yan-Tong Guo, Yan Lu, Yi-Yang Jia, Hui-Nan Qu, Da Qi, Xin-Qi Wang, Pei-Ye Song, Xiang-Shu Jin, Wen-Hong Xu, Yuan Dong, Ying-Ying Liang, Cheng-Shi Quan
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Table 2 Pin1 and c-Jun statuses according to Age, Lymph node status, Tumor size, P16 and Ki67. |
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Characteristics | No. | Pin1 status | P value | C-jun statuses | P value |
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Negative No. (%) | Positive No. (%) | Negative No. (%) | Positive No. (%) |
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Age (years) | <50 | 10 | 4 | 6 | 0.724 | 1 | 9 | 0.662 | ≥50 | 18 | 6 | 12 | 1 | 17 | Lymph node status | Absent | 22 | 10 | 12 | 0.039 | 2 | 20 | 0.443 | Present | 6 | 0 | 6 | 0 | 6 | Tumor size | ≤4 cm | 25 | 9 | 16 | 0.927 | 2 | 23 | 0.611 | >4 cm | 3 | 1 | 2 | 0 | 3 | p16 | Negative | 0 | 0 | 0 | NA | 0 | 0 | NA | Positive | 28 | 10 | 18 | 2 | 26 | Ki67 | 1%-25% | 0 | 0 | 0 | 0.014 | 0 | 0 | <0.001 | 25%-50% | 0 | 0 | 0 | 0 | 0 | 50%-75% | 3 | 3 | 0 | 2 | 1 | >75% | 25 | 7 | 18 | 0 | 25 |
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