Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia

Leng Zikuan, Zhu Rongjia, Hou Wei, Feng Yingmei, Yang Yanlei, Han Qin, Shan Guangliang, Meng Fanyan, Du Dongshu, Wang Shihua, Fan Junfen, Wang Wenjing, Deng Luchan, Shi Hongbo, Li Hongjun, Hu Zhongjie, Zhang Fengchun, Gao Jinming, Liu Hongjian, Li Xiaoxia, Zhao Yangyang, Yin Kan, He Xijing, Gao Zhengchao, Wang Yibin, Yang Bo, Jin Ronghua, Stambler Ilia, Lim Lee Wei, Su Huanxing, Moskalev Alexey, Cano Antonio, Chakrabarti Sasanka, Min Kyung-Jin, Ellison-Hughes Georgina, Caruso Calogero, Jin Kunlin, Zhao Robert Chunhua

Table 2 The general information of the enrolled patients.

Case 1 Case 2 Case 3 Case 4 Case 5 Case 6 Case 7 Ctrl 1 Ctrl 2 Ctrl 3 Gender M F F F M M M F F F Age (years) 65 63 65 51 57 45 53 75 74 46 COVID-19 type Critically severe Severe Severe Common Common Severe Severe Severe Severe Severe Fever (?, baseline) 38.6 37.7 38.2 38.5 38.4 39.0 39.0 36.0 38.9 37.7 Shortness of breath +++ +++ ++ + + +++ +++ +++ ++ + Oxygen saturation at rest state 89% 93% 92% 95% 94% 92% 90% 91% 92% 93% Cough, weak, poor appetite ++ + ++ + ++ ++ ++ + ++ + Diarrhea - - + - - - - - - - Date of diagnosed Jan 23 Jan 27 Jan 25 Feb 3 Feb 2 Jan 27 Feb 3 Feb 3 Feb 6 Feb 5 Date of intervention (MSCs or Placebo) Jan 31 Feb 2 Feb 4 Feb 4 Feb 4 Feb 6 Feb 6 Feb 8 Feb 6 Feb 6 Date of recovery Feb 3 Feb 4 Feb 6 Discharged Feb 6 Discharged Feb 5 Discharged Feb 7 Feb 7 Dead ARDS Stable