Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia

Leng Zikuan, Zhu Rongjia, Hou Wei, Feng Yingmei, Yang Yanlei, Han Qin, Shan Guangliang, Meng Fanyan, Du Dongshu, Wang Shihua, Fan Junfen, Wang Wenjing, Deng Luchan, Shi Hongbo, Li Hongjun, Hu Zhongjie, Zhang Fengchun, Gao Jinming, Liu Hongjian, Li Xiaoxia, Zhao Yangyang, Yin Kan, He Xijing, Gao Zhengchao, Wang Yibin, Yang Bo, Jin Ronghua, Stambler Ilia, Lim Lee Wei, Su Huanxing, Moskalev Alexey, Cano Antonio, Chakrabarti Sasanka, Min Kyung-Jin, Ellison-Hughes Georgina, Caruso Calogero, Jin Kunlin, Zhao Robert Chunhua

Table 3 Symptoms, signs and maximum body temperatures of the critically severe patient from Jan 21 to Feb 13, 2020. ICU: Intensive Care Unit; NA: Not Available.

Home Hospital Hospital ICU ICU ICU ICU ICU Out of ICU Hospital Hospital Date Jan 21~22 Jan 23 Jan 24~29 Jan 30 Jan 31 Feb 1 Feb 2~3 Feb 4 Feb 5~8 Feb 9~12 Feb 13 Fever (?) 37.5 37.8 37.0~38.5 38.6 38.8 36.8 36.6~36.9 36.8 36.6~36.8 36.5~36.9 36.6 Shortness of breath - + + ++ ++++ ++ + - - - - Cough + + + ++ ++ + + - - - - Sputum + + + ++ ++ + + - - - - O2 saturation (without/with O2 uptake) NA/NA NA/NA 97% /NA 91%/ 95% 89% /94% NA /98% NA /97% NA /96% NA /97% 96% //NA 97% /NA Respiratory rate NA 23 23 27 33 22 22 21 20~22 20~22 21 Treatment (Basics-1: Antipyretic, antiviral and supportive therapy. Basics-2: antiviral and supportive therapy) NA NA Basics-1 Basics-1; Mask O2 5L/min Basics-1; Mask O2 10L/min; Cell transplant Basics-1; Mask O2 5L/min Basics-2; Mask O2 5L/min Basics-2; Mask O2 5L/min Basics-2; Mask O2 5L/min Basics-2 Basics-2 RT-PCR of the virus NA Positive NA NA NA NA NA NA Positive (Feb 6) NA Negative