Comorbid Chronic Diseases are Strongly Correlated with Disease Severity among COVID-19 Patients: A Systematic Review and Meta-Analysis
Liu Hong, Chen Shiyan, Liu Min, Nie Hao, Lu Hongyun
Table 1 Characteristics of the included studies and meta-analysis of the clinical symptoms and comorbid chronic diseases in patients with COVID-19.
Study[ref]aNOSDates (mm. yy)n
Age (years)Age ≥50 years (%)Symptoms (%)
Comorbidities(%)
AllMFfevercoughfatigue or myalgiashortness of breath or dyspneadiarrheadiabeteshypertensionCAD/CVDchronic pulmonary disease
Guan et al.,2020 [3]812.19-01.20109964045947.044.088.767.838.118.73.87.415.02.51.1
Chen et al.,2020 [4]701.20-01.2099673255.567.782.881.811.031.32.013.0b40.01
Huang et al.,2020 [18]612.19-01.2041301149.048.898.076.044.055.03.020.015.015.02.0
Liu et al.,2020 [8]712.19-01.20137617655.0b81.848.232.119.08.010.29.57.31.5
Shi et al.,2020 [22]612.19-01.2081423949.549.473.059.0b42.04.012.015.010.011
Song et al.,2020 [20]601.20-01.2051252649.047.196.047.031.014.010.06.010.02.02.0
Yang et al.,2020 [6]712.19-01.2052351759.755.098.077.011.563.5b17.0b10.08
Xu et al.,2020 [19]701.20-01.2062352741.0b77.081.052.0b8.02.08.0b2.0
Zhang et al.,2020 [15]801.20-02.20140716957.070.078.664.364.331.412.912.130.05.02.8
Wu et al.,2020 [16]701.20-02.2080394146.035.078.863.822.537.51.36.3b31.31.25
Hu et al.,2020 [14]601.20-02.202481632.537.520.88.38.3bb8.38.34.20.0
Huang et al.,2020 [17]712.19-01.2034142056.2b94.150.064.714.714.711.823.517.68.8
Yang et al.,2020 [13]801.20-02.20149816845.1b76.558.43.41.37.46.0b18.80.7
Wang et al.,2020 [5]701.20-01.20138756356.0b98.659.469.631.210.110.131.214.52.9
Xu et al.,2020 [21]701.20-02.2090395150.0b78.063.028.0b6.06.019.03.01.0
Li et al.,2020 [12]701.20-02.2083443945.5b86.778.318.110.88.47.86.01.26.0
Shi et al.,2020 [23]801.20-02.1041620521164b80.334.613.228.13.814.430.510.62.9
Bhatraju et al.,2020[24]602.20-03.202415964b50.088.0b88.0b58.0bb16.7
Feng et al.,2020 [25]701.20-02.2047627120553b81.956.511.622.910.310.323.78.04.6
Du et al.,2020 [26]812.19-02.20179978257.672.698.981.639.749.721.818.432.416.24.5
Liu et al.,2020 [27]612.19-01.2078393938b73.143.6bbb6.410.3b2.6
Grasselli et al.,2020 [28]802.20-03.20159113042876387.2bbbbb11.332.014.02.6
Richardson et al.,2020[29]803.20-04.205700343722636378.530.4bb17.3b31.853.016.98.4
Simonnet et al.,2020[30]702.20-04.201249034601.00bbbbb22.648.4bb
Total/Overall12.19-04.20109486764418452.4c
(32.5-64.0)d
Prevalencee59.079.061.032.031.07.010.020.08.03.0
95% CI49.0-68.065.0-92.054.0-69.021.0-43.025.0-
37.0
5.0-9.08.0-12.015.0-26.03.0-12.01.0-3.0
I2 (%)98.599.795.198.597.481.173.094.298.094.5